Wrinkle relaxers have transformed aesthetic medicine, allowing patients to reduce dynamic wrinkles and maintain a smooth, refreshed appearance. Traditionally, options such as Botox have provided results that last three to four months. Daxxify, a new FDA-approved botulinum toxin, is changing expectations by delivering results lasting a median of six months in clinical trials. At Injection Artistry in Newport Beach, Naomi Barrett, NP-C, a internationally renowned trainer and highly sought-after expert injector, was among the first in the area to bring Daxxify to her patients. Her approach prioritizes natural movement, safety, and longevity of results, helping patients determine whether Botox, Dysport, or Daxxify is the right choice for their aesthetic goals.
Clinical Evidence for Daxxify’s Longevity
Phase 3 randomized, double-blind studies demonstrated that Daxxify produced a median duration of improvement in glabellar lines of approximately 24 weeks, significantly longer than Botox’s typical duration of effect (Dover et al., 2022). Across multiple treatment cycles, patients consistently experienced sustained wrinkle reduction with a similar safety profile to onabotulinumtoxinA (Carruthers et al., 2022).
The Key Differences of Daxxify When Compared to Botox
Daxxify differs from Botox primarily in its formulation. Rather than being stabilized with human serum albumin, Daxxify uses a proprietary peptide-based technology that allows for prolonged binding at the neuromuscular junction, thereby extending its duration of effect. This unique formulation accounts for its median six-month longevity while maintaining a comparable safety profile to other neuromodulators.
Patients treated with Daxxify typically begin noticing results within one to two days, with full results visible by two weeks. Most patients experience minimal redness or swelling at injection sites, which resolves within hours to days. Because the treatment lasts longer, patients appreciate fewer visits per year, often just two or three appointments compared to four or more with Botox.
While Daxxify can provide up to four to six months of results, individual experiences vary based on metabolism, muscle strength, and dosing. Patients who have historically metabolized toxins quickly may find Daxxify particularly helpful, but no treatment is permanent; gradual return of muscle movement and lines should be expected over time.
Daxxify represents a major advancement in wrinkle relaxer technology, supported by rigorous clinical data and offering patients longer intervals between treatments. Naomi Barrett, NP-C, provides expert guidance to help patients choose the right neuromodulator for their needs, ensuring results that are effective, natural, and tailored to their lifestyle.
References
Carruthers, J., et al. (2022). DaxibotulinumtoxinA for Injection for the Treatment of Glabellar Lines: Results from a Phase 3, Randomized, Double-Blind, Placebo-Controlled Study. Journal of the American Academy of Dermatology, 87(3), 589–598.
Dover, J. S., et al. (2022). Extended Duration of Effect with DaxibotulinumtoxinA for Injection in the Treatment of Glabellar Lines: Results from the SAKURA 1 and 2 Trials. Journal of the American Academy of Dermatology, 86(1), 34–43.
Fabi, S. G., et al. (2022). Safety and Efficacy of DaxibotulinumtoxinA for Injection Across Multiple Treatment Cycles: Results from the SAKURA 3 Open-Label Study. Dermatologic Surgery, 48(5), 503–510.
